Chinese Journal of Tissue Engineering Research ›› 2011, Vol. 15 ›› Issue (1): 130-134.doi: 10.3969/j.issn.1673-8225.2011. 01.029

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Bone marrow mesenchymal stem cells labeled with superparamagnetic iron oxide

Hu Biao1,2, Qiu Wei1,2, Meng Zeng-dong1,2    

  1. 1Department of Orthopaedics, Kunhua Hospital Affiliated to Kunming Medical College, Kunming  650032, Yunnan Province, China
    2Department of Orthopaedics, Yunnan First People’s Hospital, Yunnan  650032, Yunnan Province, China
  • Received:2010-09-02 Revised:2010-10-20 Online:2011-01-01 Published:2011-01-01
  • Contact: Meng Zeng-dong, Department of Orthopaedics, Kunhua Hospital Affiliated to Kunming Medical College, Kunming 650032, Yunnan Province, China; Department of Orthopaedics, Yunnan First People’s Hospital, Yunnan 650032, Yunnan Province, China menggu7119@vip.sina.com
  • About author:Hu Biao★, Studying for master’s degree, Department of Orthopaedics, Kunhua Hospital Affiliated to Kunming Medical College, Kunming 650032, Yunnan Province, China; Department of Orthopaedics, Yunnan First People’s Hospital, Yunnan 650032, Yunnan Province, China Hubiao56@163.com
  • Supported by:

    the Application Basic Research Foundation of Yunnan Province, No.2010CD195

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Abstract:

BACKGROUND: At present, superparamagnetic iron oxide labeled bone marrow mesenchynal stem cells (BMSCs) have been rapidly applied in the treatment of heart, liver, kidney and central nervous system disease.
OBJECTIVE: To summarize the present situation and progress about superparamagnetic iron oxide labeled BMSCs at home and abroad.
METHODS: The database of CNKI and PubMed (2001-12/2009-12) was used to search the related articles about superparamagnetic iron oxide labeled BMSCs. Key words were “superparamagnetic iron oxide, stem cells, label, magnetic resonance imaging” that were searched in title and abstract. The articles related to superparamagnetic iron oxide labeled BMSCs published in recently five years, and for articles in the same field, those published recently or in authorized journals were selected. There were 243 articles after the initial survey. A total of 40 articles related to superparamagnetic iron oxide labeled BMSCs were included according to inclusion criteria for this review.
RESULTS AND CONCLUSION: In previous studies addressing stem cell markers identified by light microscope, traditional histopathological examination was utilized, and the tissues were obtained in vivo. These are not suitable for dynamic observation, and not fit for clinical study. Superparamagnetic iron oxide can be used to effectively label living cells. This method cannot affect cell viability, growth, division, migration and differentiation, does not have cytotoxicity, with good safety, and magnetic resonance imaging can be utilized for in vivo tracer study.

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